Who Keto may not be for (or maybe there is a way to make it for you)

There are people who just can’t seem to get into ketosis or just can’t seem to lose weight on Keto. There may be a reason but it is rare.

There is a gene called PPAR-Alpha that is responsible for fat metabolism and ketogenesis. There is approximately 2% of the population that has a mutation of this gene that makes it difficult for them to achieve and maintain ketosis.

What is PPAR-Alpha

Some of the symptoms that may be present in these people are:

1. Trouble fasting without feeling absolutely terrible and potentially gaining while fasting
2. Trouble getting into ketosis all together
3. not losing weight at all

Now being that this is so very rare, don’t automatically assume you are one of these people. Make sure you’ve got your macros down and are doing this right. In addition, check ketones. If you are following the Common Sense Keto plan you will have ketones well above 0.5 mmol/L. If you are following the plan to a T and still cannot achieve over 0.5 mmol/L then potentially you have this mutation. If you have above 0.5 mmol/L yet still aren’t losing weight, this is likely not your issue.

How can you find out if you have this mutation? You can do testing through a company called 23andMe.


This only gives you the raw data then you will have to use a 3rd party to map the gene. You can use one like this:


Once you figure out if you have this rare mutation then it is up to you to decide if you want to continue keto. There are ways around it potentially.

There are 3 supplements that seem to stimulate ketogenesis even in people with this mutation.

TTA – TTA Supplement from Amazon

CLA – CLA supplement from Amazon

Sesamin – Sesamin supplement from Amazon

TTA seems to be the most effective of the 3 but the 3 combined may be beneficial.

Remember, just because you are not losing as fast as you like does not mean you have this mutation and just because you have this mutation does not mean you can’t find success with Keto.


Coach Jack McAnespy

If you want to get your Ketogenic Diet back to a place of Common Sense and learn how to heal your metabolism you can get personalized coaching from Coach Jack.

Check the details here:

Personalized Coaching with Coach Jack