LDL is NOT associated with Heart Disease!!!! Stop with the madness!!!

This is something that really grinds my gears. Every day we have someone posting in the facebook group about how their LDL is up and their doctor is putting the fear of god into them and telling them their heart will explode if they don’t get on a statin ASAP!

Here is a study that really makes me fume.

LDL levels in 136,905 people hospitalized for heart attacks did not indicate risk

Here are the parts that really get me:

1. The general consensus for a health LDL level is:

– Less than 160 if you have less than 2 other risk factors (family history/diabetes/etc)
– Less than 130 with 2 or more risk factors
– Less than 100 if you have had a prior event (heart attack)

Now if you look at the data, the average LDL score was 104. Well below the normal range. Furthermore, if you look at the study they show that half of all admissions had LDL less than 100! What is more telling is that more than half of the admission had less than 40mg/DL of HDL when the optimum level is more like 50.

2. If you look at the below chart you will see the vast majority of all events occurred in those with LDL of less than 160mg/DL which is the acceptable level. Here in Canada we don’t even discuss LDL when it is below 190mg/DL Why? Is US LDL more dangerous than Canadian LDL? This is suspicious at best.

Even beyond that, look at the highest level. People that have 220mg/DL have a far less chance of heart attack than those that have levels well below the 70mg/LD level. 10 fold less chance. If LDL is causal how does this data explain that?

3. The take away from this was that LDL targets are too high!

What? How on gods green earth does that make sense? Looking again at the chart above you can see that this doesn;t make sense. People with LDL of 200 had the same rate of heart attack as those with 30mg/DL! What good does lowing LDL more do? Clearly nothing. The only thing that I can gather here is that you want to have 30 or below or 200 or higher and you are good to go. How does that make LDL a valuable marker for anything? It doesn’t. This is nothing but straw grasping and an attempt to increase statin drug sales. It is clear.

Study after study mimics these same results. People have all ranges of LDL and still have heart attacks yet there are a few commonalities. They all have low HDL and higher triglycerides. This is a sign of inflammation. Inflammation causes heart attacks not LDL.

If LDL was causal then the charts would look much different. They would look like this:

At the end of the day does it make any sense looking at this report that we can use LDL as a marker for health. It makes far more sense that risk is more associated with inflammation and most importantly, high glucose and insulin levels. These are causing the damage and LDL is just doing it’t job by bringing cholesterol to fix the problems.

Like blaming fire fighters for fires because they are at the scene. This needs to end.

One last example to show that LDL is not a cause. Familial Hypercholesterolemia.

Before the rise of processed food and sugar consumption these people lived just as long or longer than anyone else and the have the highest level of LDL of anyone. Today they tend to have the highest risk of CVD but that is only correlated in with people that are overweight and diabetic. If you look at the population of fit and healthy people with FH they see a similar risk profile to anyone else. More over, they tend to have a higher survival rate when they do have heart attacks.

This is an article I wrote that discusses this in more detail and has 2 studies linked.

More about Familial Hypercholesterolemia

If these people were not at risk before and still don’t seem to be at risk if they are not diabetic or overweight then LDL has no relevance. It is the inflammation.

Keto ON!

Coach Jack

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5 Replies to “LDL is NOT associated with Heart Disease!!!! Stop with the madness!!!”

  1. I am concerned by this data and your conclusions. The way I read the data is that you have to take into account the percentages of people in each level of LDL. For instance if 90% of the population has LDL below 200 and people across the range have an equal incident probability of 2%, out of a total cohort of 100,000 people, then 1800 will have an incident with LDL below 200, and 20 will have have an incident with LDL above 200.
    It appears that you are 90 times better off having the very high LDL but in fact the chances of an incident are equal.

    This is very important to me as my LDL has shot up to 364 from 111 after 6 months of keto

    1. What matters is not the LDL at all. It is your Trigs and your HDL. There has yet to be a study that shows anyone with low trigs and high HDL has more risk than anyone with low LDL regardless of their LDL level.

      If you are concerned then be concerned. That is your prerogative. I am not concerned in the slightest. The data is very clear and concise. More people with LDL below the optimal levels have heart attacks than anyone else and that data is also very clear. 75% of all heart attack cases are in people with LDL of 104 or lower. How do you get anything other than a negative correlation from this data? Look at the numbers. Even the authors realise that this is the case but unfortunately their conclusion was that the targets need to be lower despite the fact that 100 years ago people were not having heart attacks at any where near the rate they are today and not a single person was on a statin or even knew what LDL was.

      1. Then I can’t understand the figures. I agree the data does say that the average LDL level of those admitted to hospital was 104. It would be interesting to know what the LDL levels of the community they came from was at the time to draw comparisons. This data does indicate that something or things other than high LDL was the cause of these patients problems, the triglycerides look high with a huge + or – variable and as you say the HDL is rather low.
        I very much hope high LDL is no problem as I have said mine has shot up!

        1. NOt sure what you mean by the community LDL? What does that have to do with anything? 75% of all people that had been admitted to that hospital had what is considered normal LDL. The optimal range is anywhere from 100 to 160 depending on your risk. Here in Canada it is actually considered fine to be below 190.

          Looking at the exact numbers it breaks down like this:

          You can see that people with an LDL of 220 have the same number of heart attacks as those at 20mg/DL. How does that even remotely show any correlation?

          The holy grail of levels is supposed to be 70mg/DL but there are 36 times more people having heart attacks at 70mg/DL than there are at 220mg/DL!

          Looking at this the safest range to be in is below 30 or above 190!

          1. When I say community I mean all the people that the hospital serves, a comparison of the LDL of those in the community compared to the admits to hospital may show something, however I don’t think we are going anywhere with this discussion. If everybody above 130 is put on statins to lower their LDL reading then the results you show will be affected. As I say I do not find this research very convincing, but I do find the research below much more interesting. Fortunately the conclusion is the same!
            ‘LDL-C does not cause Cardiovascular disease; a comprehensive review of the current literature’
            Uffe Ravnskov and co.

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